STRONG PROTECTIVE EFFECT OF THE APOL1 P.N264K VARIANT AGAINST G2-ASSOCIATED FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND KIDNEY DISEASE

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Abstract African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans.Two coding variants (G1 and G2) in the APOL1 gene play a major role in this disparity.While 13% of African Americans carry the high-risk recessive threadheaders.shop genotypes, on

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