Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
Abstract African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans.Two coding variants (G1 and G2) in the APOL1 gene play a major role in this disparity.While 13% of African Americans carry the high-risk recessive threadheaders.shop genotypes, on